Scientific Publications

1979

H. A. Tennekes (Ph.D. Thesis)

The relationship between microsomal enzyme induction and liver tumour formation.

Agricultural Research Report 890, Centre for Agricultural Publishing & Documentation, Wageningen

1978

H. A. Tennekes and A.S. Wright

The relationship between biotransformation pathways of chemicals and hepatic tumorigenesis in various strains and species.

In: Primary Liver Tumours, pp. 305-318, MTP Press (UK)

1979

H.A. Tennekes, A. S. Wright and K.M. Dix

The effects of dieldrin, diet and other environmental components on enzyme function and tumor incidence in livers of male CF-1 mice.

In: Arch. Toxicology Suppl. 2, 197-212

1981

Tennekes, A. S. Wright, K. M. Dix, and J. H. Koeman

Effects of dieldrin, diet and bedding on enzyme function and tumor incidence in livers of male CF-1 mice.

In: Cancer Research 41, 3615-3620

pdfcancer research paper 1981.pdf992.95 KB

1982

H.A. Tennekes, L. Edler, and H. W. Kunz

Dose-response analysis of the enhancement of liver tumor formation in CF-1 mice by dieldrin.

In: Carcinogenesis 3, 941-945

pdfdieldrin liver tumor enhancement in mice first paper 1982.pdf517.68 KB

1982

W. Kunz, G. Schaude, M. Schwarz, and H.A. Tennekes

Quantitative aspects of drug-mediated tumor promotion in liver, and its toxicological implications

In: Carcinogenesis 7, 111-125, Raven Press, New York

1982

D. Schrenk, M. Schwarz, H.A. Tennekes, and W. Kunz

A novel pathway of nitrosamine metabolism in liver microsomes: denitrosation of nitrosamines by cytochrome P-450.

In: Biological Reactive Intermediates II, pp. 1157-1163, Plenum Publishing Corporation, New York

1982

D. Kitta, M. Schwarz, H.A. Tennekes, H. Uehleke and W. Kunz

Covalent binding of CCl4-intermediates to reduced pyridine nucleotides in mouse liver.

In: Biological Reactive Intermediates II, pp. 769-777, Plenum Publishing Corporation, New York

1983

H. W. Kunz, H.A. Tennekes, R. E. Port, M. Schwarz, D. Lorke, and G. Schaude

Quantitative aspects of chemical carcinogenesis and tumor promotion in liver

In: Env. Health Persp., 50, pp. 113-122

1985

H.A. Tennekes, B. van Ravenzwaay, and H.W. Kunz

Quantitative aspects of enhanced liver tumour formation in CF-1 mice by dieldrin.

In: Carcinogenesis 6, 1457-1462

pdfdieldrin liver tumor enhancement in mice 1985.pdf484.36 KB

1985

H. W. Kunz, M. Schwarz, H, Tennekes, R. Port, and K. Appel

Mechanism and dose-time response characteristics of carcinogenic and tumor promoting xenobiotics in liver.

In: Tumorpromotoren, BGA Schriften 6, pp. 76-97, MMV Medizin Verlag, München

1987

B. van Ravenzwaay, H.A. Tennekes, M. Stöhr, and W. Kunz

The kinetics of nuclear polyploidisation and tumour formation in livers of CF-1 mice exposed to dieldrin.

In: Carcinogenesis 8, 265-269 2002

pdfdieldrin polyploidy enhancement in mice 1987.pdf379.47 KB

2002

B. van Ravenzwaay and H. Tennekes

A Wistar rat strain prone to spontaneous liver tumor development. Implications for carcinogenic risk assessment

In: Regulatory Toxicology and Pharmacology 36, 86-95

pdfRTP Liver Tumor Drift final 2002.pdf104.55 KB

2004

H. Tennekes, C. Gembardt, M. Dammann and B. van Ravenzwaay

The stability of historical control data for common neoplasms in laboratory rats: adrenal gland (medulla), mammary gland, liver, endocrine pancreas and pituitary gland.

In: Regulatory Toxicology and Pharmacology 40, 18-27

pdfRTP Historical controls 1 final 2004.pdf151.79 KB

2004

H. Tennekes, W. Kaufmann, M. Dammann and B. van Ravenzwaay

The stability of historical control data for common neoplasms in laboratory rats and the implications for carcinogenic risk assessment.

In: Regulatory Toxicology and Pharmacology 40, 293-304

pdfRTP Historical controls 2 final 2004.pdf300.73 KB

2004

A.O. Gamer, E. Leibold, K. Deckardt, B. Kittel, W. Kaufmann, H.A. Tennekes, and B. van Ravenzwaay

The effects of styrene on lung cells in female mice and rats.

In: Food Chem Toxicol. 42(10):1655-67

pdfStyrene Lung Cells 2004.pdf662.41 KB

2007

K. Deckardt, I. Weber, U. Kaspers, J. Hellwig, H. Tennekes, and B. van Ravenzwaay

The effects of inhalation anaesthetics on common clinical pathology parameters in laboratory rats.

In: Food Chem Toxicol. 45(9),1709-18

pdfANESTHETICS CLINICAL PATHOLOGY 2007.pdf206.58 KB

2009

G. Coelho Palermo Cunha, B. van Ravenzwaay, H.A. Tennekes, W. Mellert, S. Schulte and S. Burkhardt

Effects of an ultraviolet B radiation absorber on photocarcinogenesis in hairless albino mice.

In: Skin Pharmacology and Physiology 22:166-176

pdfUV CARCINOGENESIS PAPER 2009.pdf542.08 KB

2010

H. Tennekes, V.A. Gretton and T. Stedeford

Hazard and risk assessment of chemical carcinogenicity within a regulatory context.

In: Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification (Edited by Ching-Hung Hsu and Todd Stedeford), pp. 37-65. John Wiley and Sons, Hoboken, NJ 07030-5774

2010

H. A. Tennekes

The significance of the Druckrey-Küpfmüller equation for risk assessment - The toxicity of neonicotinoid insecticides to arthropods is reinforced by exposure time.

In: Toxicology 276, 1-4

pdfTennekes 2010 Toxicology.pdf138.93 KB

2010

H. A. Tennekes

The Systemic Insecticides: A Disaster in the Making

book by ETS Nederland BV, Zutphen, The Netherlands

2011

H. A. Tennekes

Das Ende der Artenvielfalt – Neuartige Pestizide töten Insekten und Vögel

Bund fuer Umwelt und Naturschutz Deutschland (BUND) – Friends of the Earth Germany, Berlin

2011

H. Tennekes

The significance of the Druckrey-Küpfmüller equation for risk assessment - The toxicity of neonicotinoid insecticides to arthropods is reinforced by exposure time: Responding to a Letter to the Editor by Drs. C. Maus and R. Nauen of Bayer CropScience AG

In: Toxicology 280, 173-175

pdfTOX50689.pdf265.21 KB

2011

H. A. Tennekes and F. Sánchez-Bayo

Time-Dependent Toxicity of Neonicotinoids and Other Toxicants: Implications for a New Approach to Risk Assessment

In: J Environment Analytic Toxicol S4:001. doi:10.4172/2161-0525.S4-001

pdfJEAT Study Tennekes Neonicotinoids.pdf2.58 MB

2013

R. Mason, H. Tennekes, F. Sánchez-Bayo, P. Uhd Jepsen

Immune Suppression by Neonicotinoid Insecticides at the Root of Global Wildlife Declines

In: Journal of Environmental Immunology and Toxicology 1, 3-12

pdfJEIT Immune Suppression.pdf900.67 KB

2013

H. A. Tennekes and F. Sánchez-Bayo

The molecular basis of simple relationships between exposure concentration and toxic effects with time

In: Toxicology 309, 39-51

pdfTennekes Sanchez-Bayo Toxicology 2013.pdf1.02 MB

2013

H. A. Tennekes, F. Sánchez-Bayo, K. Goka

Impact of Systemic Insecticides on Organisms and Ecosystems

In: Insecticides-Development of Safer and More Effective Technologien (Ed. Stanislav Trdan), pp. 365-414. InTech Open Science ISBN:980-953-307-514-8

pdfInTech-Impact of systemic insecticides on organisms and ecosystems.pdf574.44 KB

2014

H. Tennekes

Wirkung der Neonicotinoide. Umweltgau in der Insektenwelt.

In: Oekoskop (Fachzeitschrift der Ärztinnen und Ärzte für Umweltschutz) Nr. 1/14, 5-8 2014

pdfOEKOSKOP-1 2014 def.pdf6.36 MB

2014

S. Mellching-Kollmuss, K.C. Fussell, R. Buesen, M. Damman, S.Schneider, H. Tennekes, B. van Ravenzwaay.

Anti-androgenicity can only be evaluated using a weight of evidence approach

In: Regul. Toxicol. Pharmacol. 68, 175-92

2014

G. Rondeau, F. Sánchez-Bayo, H.A. Tennekes, A.Decourtye, R.Ramirez-Romero, N. Desneux

Delayed and time-cumulative toxicity of imidacloprid in bees, ants and termites.

In: Sci. Rep. 4, 5566; DOI:10.1038/srep05566 (www.nature.com/scientificreports)

pdfRondeau Nature Scientific Reports 2014.pdf1.04 MB

 

 

  

Published Manucripts Prepared by Henk Tennekes for BASF

2002

Gamer AO, Jaeckh R, Leibold E, Kaufmann W, Gembardt C, Bahnemann R, van Ravenzwaay B.
Investigations on cell proliferation and enzyme induction in male rat kidney and female mouse liver caused by tetrahydrofuran.
In: Toxicol Sci. 2002 Nov;70(1):140-9.

Link: http://www.ncbi.nlm.nih.gov/pubmed/12388842?dopt=Abstract

2002

van Ravenzwaay B, Tennekes H.
A Wistar rat strain prone to spontaneous liver tumor development: implications for carcinogenic risk assessment.
In: Regul Toxicol Pharmacol. 2002 Aug;36(1):86-95.

Link: http://www.ncbi.nlm.nih.gov/pubmed/12383721?dopt=Abstract

2003

van Ravenzwaay B, Gamer AO, Leibold E, Kaufmann W.
Effect of cytochrome P-450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female mice.
In: Arch Toxicol. 2003 Aug;77(8):459-64.

Link: http://www.ncbi.nlm.nih.gov/pubmed/12802580?dopt=Abstract

2004

Tennekes H, Kaufmann W, Dammann M, van Ravenzwaay B.
The stability of historical control data for common neoplasms in laboratory rats and the implications for carcinogenic risk assessment.
In: Regul Toxicol Pharmacol. 2004 Dec;40(3):293-304.

Link: http://www.ncbi.nlm.nih.gov/pubmed/15546683?dopt=Abstract

2004

van Ravenzwaay B, Leibold E.
A comparison between in vitro rat and human and in vivo rat skin absorption studies.
In: Hum Exp Toxicol. 2004 Aug;23(9):421-30.

Link: http://www.ncbi.nlm.nih.gov/pubmed/15497817?dopt=Abstract

2004

Mellert W, Deckardt K, Gembardt C, Zwirner-Baier I, Jackh R, van Ravenzwaay B.
Aniline: early indicators of toxicity in male rats and their relevance to spleen carcinogenicity.
In: Hum Exp Toxicol. 2004 Aug;23(8):379-89.

Link: http://www.ncbi.nlm.nih.gov/pubmed/15346719?dopt=Abstract

2004

Gamer AO, Leibold E, Deckardt K, Kittel B, Kaufmann W, Tennekes HA, van Ravenzwaay B.
The effects of styrene on lung cells in female mice and rats.
In: Food Chem Toxicol. 2004 Oct;42(10):1655-67.

Link: http://www.ncbi.nlm.nih.gov/pubmed/15304312?dopt=Abstract

2004

Tennekes H, Gembardt C, Dammann M, van Ravenzwaay B.
The stability of historical control data for common neoplasms in laboratory rats: adrenal gland (medulla), mammary gland, liver, endocrine pancreas, and pituitary gland.
In: Regul Toxicol Pharmacol. 2004 Aug;40(1):18-27.

Link: http://www.ncbi.nlm.nih.gov/pubmed/15265603?dopt=Abstract

2004

van Ravenzwaay B, Leibold E.
The significance of in vitro rat skin absorption studies to human risk assessment.
In: Toxicol In Vitro. 2004 Apr;18(2):219-25.

Link: http://www.ncbi.nlm.nih.gov/pubmed/14757113?dopt=Abstract

2004

Mellert W, Kaufmann W, Rossbacher R, van Ravenzwaay B.
Investigations on cell proliferation in B6C3F(1) mouse liver by diethanolamine.
In: Food Chem Toxicol. 2004 Jan;42(1):127-34.

Link: http://www.ncbi.nlm.nih.gov/pubmed/14630136?dopt=Abstract

2005

Gamer AO, Leibold E, van Ravenzwaay B.
The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin.
In: Toxicol In Vitro. 2005 Sep 20

Link: http://www.ncbi.nlm.nih.gov/pubmed/16182508?dopt=Abstract

2005

van Ravenzwaay B, Mellert W, Deckardt K, Kuttler K.
The comparative toxicology of 4-chloro-2-methylphenoxyacetic acid and its plant metabolite 4-chloro-2-carboxyphenoxyacetic acid in rats.
In: Regul Toxicol Pharmacol. 2005 Jun;42(1):47-54.

Link: http://www.ncbi.nlm.nih.gov/pubmed/15896442?dopt=Abstract

2005

Kaufmann W, Mellert W, van Ravenzwaay B, Landsiedel R, Poole A.
Effects of styrene and its metabolites on different lung compartments of the mouse--cell proliferation and histomorphology.
In: Regul Toxicol Pharmacol. 2005 Jun;42(1):24-36.

Link: http://www.ncbi.nlm.nih.gov/pubmed/15896440?dopt=Abstract

2005

Cunha GC, van Ravenzwaay B.
Evaluation of mechanisms inducing thyroid toxicity and the ability of the enhanced OECD Test Guideline 407 to detect these changes.
In: Arch Toxicol. 2005 Jul;79(7):390-405.

Link: http://www.ncbi.nlm.nih.gov/pubmed/15692820?dopt=Abstract

 

 

  

Unpublished Study Reports now in the Public Domain

1987

Tennekes, H., Horst, K., Luetkemeier, H., Vogel, W., Schlotke, B. & Terrier, C.H. 

Triazophos. Subchronic oral toxicity, 13 week feeding study in rats. 

Unpublished report No. 071818 from RCC Research & Consulting Company AG, Itingen, Switzerland, 10 December 1987. Aventis document A37398. Submitted to WHO by Aventis CropScience, Frankfurt am Main, Germany. 

1987

Tennekes, H., Horst, K., Luetkemeier, H., Wilson, J., Vogel, W., & Terrier, Ch. 

Thirteen week oral toxicity (feeding) study with Bentazone Technical (ZNT No. 86/48) in the rat. 

Unpublished report by RCC Research & Consulting Company AG, Itingen, Switzerland, submitted to WHO by BASF, Limburgerhof, Germany.

1989

Tennekes, H., Stucki, P., Luetkemeier, H., Biedermann, K., Bloch, M., Chevalier, H., Vogel, O. & Terrier, C. 

Chronic toxicity and oncogenicity (feeding) study with CME 134 in the rat. Project 064192. Document No. 134AB-437-009.

Unpublished report from RCC Research & Consulting Company AG, Itingen, Switzerland. Submitted to WHO by Shell International Chemical Co. Ltd, London, United Kingdom. 

1989

Tennekes, H., Horst, K., Luetkemeier, H., Vogel, W., Vogel, O., Armstrong, J., Ehlers, H.A., Muller, E., Terrier, C.

TPTH-technical (Code: HOE 029664 OF ZD97 0004: Oncogenicity 80-week feeding study in mice. 

Unpublished report 047002 (A40467) from RCC Research & Consulting Company AG, Itingen, Switzerland. Submitted to WHO by Hoechst AG, Frankfurt-am-Main, Germany. 

1989

Tennekes, H., Horst, K., Luetkemeier, H., Vogel, W., Schlotke, B., Vogel, O., Ehlers, H.A., Muller, E., Terrier, C.

TPTH-technical (Code: HOE 029664 OF ZD97 0007): Chronic toxicity/oncogenicity 104-week feeding study in rats. 

Unpublished report 046980 (A40468) of RCC Research & Consulting Company AG, Itingen, Switzerland. Submitted to WHO by Hoechst AG, Frankfurt-am-Main, Germany.

1990

Tennekes, H., Janiak, T., Probst, D., Luetkemeier, H., Vogel, O., Westen, H., Biedermann, K. & Heusner, W.

Triazophos. Chronic toxicity/oncogenicity feeding study in rats.

Unpublished report No. 071537 from RCC Research & Consulting Company AG, Itingen, Switzerland, 24 December 1990. Aventis document A44716. Submitted to WHO by Aventis CropScience, Frankfurt am Main, Germany.  

1991

Tennekes, H., Janiak, T., Probst, D., Luetkemeier, H., Vogel, O., Schlotke, B., Biedermann, K., & Heusner, W.

Pyrazophos substance technical. Chronic toxicity/oncogenicity feeding study in rats. 

Unpublished report No. 071526 from RCC Research & Consulting Company AG, Itingen, Switzerland. Submitted to WHO by Hoechst. 

1991

Tennekes, H., Janiak, T., Probst, D., Luetkemeier, H., Vogel, O., Schlotke, B., Biedermann, K., & Heusner, W.

Pyrazophos substance technical. Chronic toxicity addendum to RCC project 071526 satellite feeding study in rats with a supplementary test concentration. 

Unpublished report No. 209226 from RCC Research &Consulting Company AG, Itingen, Switzerland. Submitted to WHO by Hoechst. 

1991

Tennekes, H., Janiak, T., Stucki, H.P., Probst, D., Luetkemeier, H., Vogel, O., Schlotke, B., Biedermann, K. & Heusner, W.

28-Day range-finding (feeding) study with chlorfenvinphos in the mouse. RCC  Project No. 243202.

Unpublished report from RCC Research & Consulting Company AG, Itingen, Switzerland. Submitted to WHO by American Cyanamid Co., Princeton, NJ, USA

1992

Tennekes, H., Schmid, H. & Probst, D. 

Sub-chronic oral toxicity 13-week feeding study in mice with Hoe 099730 substance, technical. RCC Research & Consulting Company Ltd, Itingen, Switzerland. Report No. 291025. A48186.

Unpublished report submitted to WHO by Hoechst Schering AgrEvo GmbH, Germany.

1992

Tennekes, H., Probst, D. & Luetkemeier, H.

Sub-chronic oral toxicity 13-week feeding study in rats with Hoe 099730 substance, technical. 
RCC Research & Consulting Company Ltd, Itingen, Switzerland. Report No. 291093. A48187.

Unpublished report submitted to WHO by Hoechst Schering AgrEvo GmbH, Germany.

1992

Schmid, H., Tennekes, H., Janiak, T., Probst, D., Leutkemeier, H., Pappritz, G., Marki, U., Vogel, O., Heusner, W.

Ethylenethiourea 104 week chronic toxicity (feeding) study in rats.

Unpublished study No. 256803 from RCC Research & Consulting Company Ltd, Itingen, Switzerland. Submitted to WHO by Rohm and Haas Company, Spring House, Pennsylvania, USA.

1994

Tennekes, H. 

The genetic toxicology of captan.

Unpublished review commissioned by Zeneca Agrochemicals. Submitted to U.S. EPA.

1995

Tennekes, H. 

The genetic toxicology of folpet.
Position paper commissioned by Makhteshim Chemical Works Ltd, Beer-Sheva, Israel.

Submitted to WHO.